Two 15-year-olds, a boy and a girl, have been arrested on suspicion of stabbing to death a 16-year-old female who was found in a park in the nearby village.
On Saturday, members of the public discovered Brianna Ghey at Linear Park in Culcheth, Warrington, Cheshire.
She was discovered lying on a path with stab wounds shortly after 15:00 GMT, prompting the dispatch of emergency personnel.
Despite Brianna’s transgender identity, detectives have found no evidence linking her murder to bias.
Teenagers from the region have been apprehended and are currently being detained.
Police are conducting multiple investigations to determine the “precise facts,” according to Det Ch Supt Mike Evans.
There is “no evidence at this moment” to suggest that Brianna’s death was motivated by hatred, he said.
Authorities have increased patrols and said officers would remain in the Culcheth neighborhood to reassure residents and answer any questions they may have.
Members of the public discovered Brianna lying injured on a path.
In an earlier statement, police said they were supporting Brianna’s family, who is from the nearby town of Birchwood, and that a post-mortem examination was being conducted to determine the cause of death.
Emma Mills, the principal of Birchwood Community High School, where Brianna studied, expressed sorrow and grief at the news of her death.
We recognize that this is a challenging and upsetting time for many, and we pledge to do everything in our power to help the students and staff of our school get through it.
It was reported that investigators were still trying to determine what motivated the attack and locate the weapon used.
The area, popular with dog walkers, is currently being patrolled by an increased number of officers.
The police are looking for witnesses and anyone with a dashcam or CCTV footage of the event.